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首頁 > 產(chǎn)品目錄 > 信號(hào)通路 > Stem Cells & Wnt | 干細(xì)胞及 Wnt 通路 > ROCK > trans-4-[(R)-1-氨基乙基]-N-(4-吡啶基)環(huán)己烷甲酰胺二鹽酸鹽 | Y-27632 二鹽酸鹽 | (R)-(+)-反式-4-(1-氨基乙基)-N-(4-吡啶基)環(huán)己烷甲酰胺 二鹽酸鹽

trans-4-[(R)-1-氨基乙基]-N-(4-吡啶基)環(huán)己烷甲酰胺二鹽酸鹽 | Y-27632 二鹽酸鹽 | (R)-(+)-反式-4-(1-氨基乙基)-N-(4-吡啶基)環(huán)己烷甲酰胺 二鹽酸鹽

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Y-27632 Dihydrochloride | Y-27632 2HCl | trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride

產(chǎn)品編號(hào)：CL1003 CAS No.：129830-38-2 MDLNo：MFCD03490488 分子式：C14H21N3O.2HCl 分子量：320.26 | 247.34(free)
規(guī)格 庫存 目錄價(jià) 會(huì)員專享價(jià) 數(shù)量
5 mg In-stock ￥650.00 登錄后可見
- +
10 mg In-stock ￥900.00 登錄后可見
- +
25 mg In-stock ￥1600.00 登錄后可見
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50 mg In-stock ￥2800.00 登錄后可見
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基本信息
英文名稱 Y-27632 Dihydrochloride | Y-27632 2HCl | trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride
中文名稱trans-4-[(R)-1-氨基乙基]-N-(4-吡啶基)環(huán)己烷甲酰胺二鹽酸鹽 | Y-27632 二鹽酸鹽 | (R)-(+)-反式-4-(1-氨基乙基)-N-(4-吡啶基)環(huán)己烷甲酰胺 二鹽酸鹽
CAS號(hào)129830-38-2
分子式C14H21N3O.2HCl
分子量320.26 | 247.34(free)
MDLMFCD03490488
外觀White to off-white powder
儲(chǔ)存條件4°C, sealed storage, away from moisture
產(chǎn)品詳情

The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. Y-27632 2HClis a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK2 (IC50 = 800 nM). It also inhibits PRK2 with an IC50 value of 600 nM. One-hour treatment with 10 μMY-27632 2HCl blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passages. 

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