英文名稱 | Varespladib | LY315920 |
---|---|
中文名稱 | 伐瑞拉迪 |
CAS號 | 172732-68-2 |
分子式 | C21H20N2O5 |
分子量 | 380.39 |
外觀 | White to yellow powder |
儲存條件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
英文名稱 | Varespladib | LY315920 |
---|---|
中文名稱 | 伐瑞拉迪 |
CAS號 | 172732-68-2 |
分子式 | C21H20N2O5 |
分子量 | 380.39 |
外觀 | White to yellow powder |
儲存條件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
Varespladib (LY315920) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively.
PMID: 16249480 PMCID: PMC1473963 DOI: 10.1167/iovs.05-0627