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MCC950 Sodium (CP-456773 Sodium)

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MCC950 Sodium (CP-456773 Sodium)

產(chǎn)品編號：CL1969 CAS No.：256373-96-3 MDLNo： 分子式：C20H23N2NaO5S 分子量：426.46
規(guī)格 庫存 目錄價(jià) 會(huì)員專享價(jià) 數(shù)量
5 mg In-stock ￥450.00 登錄后可見
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10 mg In-stock ￥800.00 登錄后可見
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25 mg In-stock ￥1350.00 登錄后可見
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50 mg In-stock ￥2430.00 登錄后可見
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基本信息
英文名稱 MCC950 Sodium (CP-456773 Sodium)
中文名稱MCC950 Sodium (CP-456773 Sodium)
CAS號256373-96-3
分子式C20H23N2NaO5S
分子量426.46
外觀Off-white to yellow powder
儲(chǔ)存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

MCC950 is an inhibitor of NOD-like receptor protein 3 (NLRP3) inflammasome activation. It inhibits ATP-induced IL-1β release in LPS-primed mouse bone marrow-derived macrophages (BMDMs; IC50 = 7.5 nM), as well as cytosolic LPS-induced IL-1β release in Pam3CSK4-primed mouse BMDMs at 0.1 and 1 μM, indicating inhibition of both canonical and non-canonical NLRP3 inflammasome activation, respectively. MCC950 is selective for NLRP3 over NLRC4 and absent in melanoma 2 (AIM2) inflammasomes and does not inhibit LPS-induced NLRP3 priming in mouse BMDMs at 10 μM. It reduces ox-LDL-induced increases in caspase-1 activity and inhibits pyroptosis in THP-1 macrophages when used at a concentration of 1 μM. MCC950 (10 mg/kg) reduces myocardial fibrosis in mice following myocardial infarction induced by left coronary artery ligation. It improves forelimb grip strength and reduces spinal edema in a mouse model of spinal crush injury at the same dose.

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