英文名稱(chēng) | Quizartinib (AC220) |
---|---|
中文名稱(chēng) | 奎扎替尼 |
CAS號(hào) | 950769-58-1 |
分子式 | C29H32N6O4S |
分子量 | 560.67 |
外觀 | White to off-white powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
規(guī)格 | 庫(kù)存 | 目錄價(jià) | 會(huì)員專(zhuān)享價(jià) | 數(shù)量 |
---|---|---|---|---|
5 mg | 3-5days | ¥450.00 | 登錄后可見(jiàn) | |
10 mg | 3-5days | ¥650.00 | 登錄后可見(jiàn) | |
25 mg | 3-5days | ¥950.00 | 登錄后可見(jiàn) |
英文名稱(chēng) | Quizartinib (AC220) |
---|---|
中文名稱(chēng) | 奎扎替尼 |
CAS號(hào) | 950769-58-1 |
分子式 | C29H32N6O4S |
分子量 | 560.67 |
外觀 | White to off-white powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Quizartinib (formerly also know as AC-220; AC-010220, Vanflyta) is a novel, potent, 2nd-generation, and orally bioavailable FLT3 tyrosine kinase inhibitor for Flt3 (ITD/WT) with potential anticancer activity.With IC50s of 1.1 nM and 4.2 nM, respectively, it inhibits FLT3 in MV4-11 and RS4EL11 cells. With respect to KIT, PDGFRα, PDGFRβ, RET, and CSF-1R, it demonstrates a ten-fold greater selectivity. Currently, Daiichi Sankyo is developing quizartinib to treat acute myeloid leukemia. Quizartinib (Vanflyta) was approved in 2023 by FDA for treating AML.