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抑肽素

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Pepstatin(Pepstatin A)

產(chǎn)品編號：CLP1109 CAS No.：26305-03-3 MDLNo： 分子式：C34 H63N5O9 分子量：685.89
規(guī)格 庫存 目錄價 會員專享價 數(shù)量
10 mg 3-5days ￥500.00 登錄后可見
- +
25 mg 3-5days ￥750.00 登錄后可見
- +
50 mg 3-5days ￥1400.00 登錄后可見
- +

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基本信息
英文名稱 Pepstatin(Pepstatin A)
中文名稱抑肽素
CAS號26305-03-3
分子式C34 H63N5O9
分子量685.89
外觀White to off-white
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

Pepstatin A (NSC-272671; NSC272671), a pentapeptide, is a potent and selective aspartic protease inhibitor which also inhibits HIV replication. Pepstatin A was originally isolated from the microbe. For the enzymes hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease, and hemoglobin-acid protease, respectively, its IC50 values are 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM, and 260 nM. At weak acid pH values, pepstatinA, a highly potent renin inhibitor, inhibited both human and porcine renin with IC50 values of 15 μM and 0.32, respectively. For aspartic proteinases like pepsin, cathepsins D and E, pepstatin A effectively inhibits them. Pepstatin A appears to have no harmful effects on HIV-infected cells, but it does block a portion of the intracellular processing of the HIV gag protein in H9 cells that have the virus. By preventing ERK signaling and reducing NFATc1 expression, pepstatin A also prevents osteoclast differentiation.

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