英文名稱 | AXL1717 (Picropodophyllotoxin; Picropodophyllin; PPP) |
---|---|
中文名稱 | 苦鬼臼毒素 |
CAS號 | 477-47-4 |
分子式 | C??H??O? |
分子量 | 414.41 |
外觀 | White to off-white powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | AXL1717 (Picropodophyllotoxin; Picropodophyllin; PPP) |
---|---|
中文名稱 | 苦鬼臼毒素 |
CAS號 | 477-47-4 |
分子式 | C??H??O? |
分子量 | 414.41 |
外觀 | White to off-white powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Picropodophyllin (PPP, AXL1717) is a IGF-1R inhibitor with IC50 of 1 nM. It displays selectivity for IGF-1R and does not coinhibit tyrosine phosphorylation the IR, or of a selected panel of receptors less related to IGF-IR(FGF-R, PDGF-R, OR EGF-R). Picropodophyllin (PPP) induces apoptosis with antineoplastic activity.